8/27/2023 0 Comments Pac man song notes![]() (A) A hypothetical life cycle of SARS-CoV-2. The Hypothetical Life Cycle of SARS-CoV-2 and the PAC-MAN Approach for Inhibiting Coronavirus Using CRISPR-Cas13 Targeting the positive-sense genome and viral mRNAs to simultaneously degrade viral genome templates for replication and viral gene expression would be expected to robustly limit viral replication. Whereas most ongoing vaccine trials work by priming the human immune system to recognize coronavirus proteins or attenuated viruses and decrease viral entry into cells ( Rappuoli, 2018), the alternative antiviral approach we propose here relies on a CRISPR-based system for recognizing and degrading the intracellular viral genome and its resulting viral mRNAs ( Figure 1B). The SARS-CoV-2 life cycle is likely similar to the closely related coronavirus that causes SARS, in which the virus enters the cell, releases its RNA genome into the cytoplasm, and synthesizes negative-sense genomic and subgenomic RNAs from which viral mRNAs and new copies of the positive sense viral genome are synthesized ( Figure 1Ī) ( Du et al., 2009, Liu, 2014). The novel coronavirus causing COVID-19 belongs to a family of positive-sense RNA viruses, which typically infect the upper and lower respiratory tracts and cause disease by direct cytotoxic effects and the induction of host cytokine-mediated inflammation ( Liu et al., 2020). A recent report showed two strains (L and S) of SARS-CoV-2 with different genomic sequences are circulating and likely evolving, further highlighting the need for a pan-coronavirus targeting strategy ( Tang et al., 2020). Because coronaviruses causing COVID-19, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS) are able to spontaneously transfer to humans from diverse animal hosts that act as viral reservoirs, there is a pressing need to develop methods to broadly combat other coronaviruses that may emerge in the future ( Li et al., 2005, Mohd et al., 2016, Shi and Hu, 2008). With a rapidly growing number of cases and deaths around the world, such emerging threats require a nimble and targeted means of protection. It is predicted that the development of a safe and effective vaccine to prevent COVID-19 will take 12 to 18 months, by which time many millions of people may have been infected. Logsdon also saw 15 minutes of fame when he won the former CMT game show “The Singing Bee” in 2009 hosted by Melissa Peterman.The world is currently faced with a pandemic of novel coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has no preventative vaccine or proven pharmacologic treatment. ![]() In addition, he’s directed PR for Buddy Lee Attractions, Classic Rockers Brownsville Station, Chase Rice, Deborah Allen, Style Network’s Donnie Brown, YouTube Sensation Jessica Frech, Mark Chesnutt, Razzy Bailey, Mrs. Mark currently serves as the PR representative for the following: Tina Turner Museum, Johnny Cash Museum, Patsy Cline Museum, Merle Haggard Museum, Merle’s Meat + 3, Skull’s Rainbow Room, Nudie’s Honky Tonk, West Tennessee Delta Heritage Center, Warner/Chappell Production Music, The Americana Music Triangle, RCA Studio A, 2017 Trop Rock Music Award Winner and co-writer of Diamond hit “Cruise” Jesse Rice, NASCAR All American, USAC Series and VRA race car driver, author and country artist Tyler Williams and celebrated “Shuffle Country” Canadian bred trio Beyond The Sun.ĭuring his tenure, he was often seen alongside the trailblazing TV and Country Icon Lynn Anderson whom he presented for the last eight years of her life. His unwavering efforts and passion for his clients has opened the doors for the company to expand beyond artist and talent representation into the tourism and festival business. ![]() ![]() Throughout the last decade at PLA, he has risen from Publicity Coordinator, Publicity & Marketing Account Executive, Senior Publicist & Marketing Executive to Executive Director at PLA Media. Before PLA, this Summa Cum Laude graduate of Middle Tennessee State University gained experience at Sony/BMG, RLM/Mission Management and the Atlantis Music Conference. Mark Logsdon, a native of Leitchfield, KY, joined PLA Media as a Publicity Coordinator in July of 2007.
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